Gastric cancer-derived exosomes induce PD-L1 expression on human bone marrow mesenchymal stem cells through the AKT-c-Myc signal axis
نویسندگان
چکیده
Mesenchymal stem cells (MSCs) show high expression of PD-L1. Exosomes can transmit signals between tumor and stromal cells; however, the effect tumor-derived exosomes on cell signaling pathways is unclear. The PD-L1 in bone marrow mesenchymal (BMMSCs) was detected by western blot RT-PCR. effects gastric cancer line-derived BMMSC migration conditioned medium from educated BMMSCs were analyzed. Our results demonstrate that derived lines activate AKT/c-Myc pathway upregulate BMMSCs. Moreover, pro-migration dependent upregulation promoted cells. In conclusion, could to promote migration. provide a new therapeutic avenue cancer.
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ژورنال
عنوان ژورنال: All life
سال: 2022
ISSN: ['2689-5293', '2689-5307']
DOI: https://doi.org/10.1080/26895293.2022.2058098